In order to perform polynomial regression, you must first select the degree of the polynomial equation that best fits your data. Criteria such as the coefficient of determination (R^2), the adjusted R^2, the root mean square error (RMSE), or the Akaike information criterion (AIC) can be used to compare different models and select the most appropriate. Then, you must transform your data by adding polynomial terms as new columns. For example, if you have a single predictor variable x and you want to fit a quadratic equation (degree 2), you need to create a new column x^2 and use both x and x^2 as predictors. After that, an ordinary least squares (OLS) linear regression technique should be applied to estimate the coefficients of the polynomial equation. Software packages such as Excel, R, or Python can be used to perform this step. Finally, it is necessary to evaluate the fit and assumptions of the polynomial regression model. Graphical methods such as scatter plots, residual plots, or leverage plots, or statistical tests like the F-test, t-test or Durbin-Watson test can be used to assess these aspects and check if the model explains a significant amount of variation in the response variable, if residuals are normally distributed with constant variance and if there are no outliers or influential points affecting the results.