The sustainability and social acceptance of uranium are crucial for the future of nuclear power generation, as they affect the environmental, economic, and social impacts and benefits of the nuclear energy system. The environmental impact of uranium includes the greenhouse gas emissions, water consumption, land use, biodiversity loss, radiation exposure, and waste generation associated with the uranium mining and power generation. The economic impact of uranium includes the capital investment, operating costs, employment, taxes, royalties, and subsidies related to the uranium mining and power generation. The social impact of uranium includes the health, safety, security, education, participation, and perception of the stakeholders and communities involved or affected by the uranium mining and power generation. The sustainability and social acceptance of uranium depend on the implementation of best practices, standards, policies, and communication that address the challenges and opportunities of the nuclear energy system.