When using t-tests, there are some common mistakes to be aware of. One is using a paired t-test when the groups are independent, or vice versa. This can lead to false positives or false negatives, so it’s important to check if the observations are matched or not and use the appropriate type of t-test. Another mistake is ignoring the assumptions of normality, equal variance, and independence. This can affect the validity and accuracy of the t-test, so it’s important to check the distributions and variances of the data, and use alternative tests or transformations if needed. Lastly, relying solely on the p-value or the significance level can miss the practical significance or effect size of the difference. To avoid this, report and interpret the confidence intervals and mean difference, and use measures like Cohen's d or eta-squared to quantify the effect size.