When programming PIC microcontrollers in C language, one of the first challenges is dealing with the hardware limitations of the device, such as limited memory, processing speed, and peripherals. To optimize code to fit the available resources, you must consider power consumption, clock frequency, and voltage levels of the device. To overcome these hardware limitations, you should use the appropriate PIC C compiler for your device and enable optimization options that suit your needs. Additionally, take advantage of built-in libraries and functions provided by the compiler to avoid redundant code. Moreover, you can reduce memory usage and improve execution speed by using macros, constants, and inline functions. Bit manipulation, bitwise operators, and bit fields can be used to access and control registers and bits of the device. Finally, interrupts, timers, and watchdogs can help handle events and tasks efficiently and reliably.