The choice between Server Core and Server with Desktop Experience depends on several factors, such as your server role and feature requirements, performance and security needs, and management preferences. If you need to run a specific server role or feature that is not supported by Server Core, or if you need to run an application or driver that is not compatible with Server Core, then you should use Server with Desktop Experience. However, if you want to optimize your server resource consumption, reduce your attack surface, and minimize your maintenance overhead, you should use Server Core. Additionally, if you are comfortable and proficient with using the command line, PowerShell, or remote tools for server administration then you should use Server Core. On the other hand, if you prefer or need a GUI for your server management or if you are not familiar or confident with using the command line, PowerShell, or remote tools then you should use Server with Desktop Experience.