Once you have prioritized the hazards, you need to plan actions to reduce or eliminate them. The actions should be based on the hierarchy of controls, a framework that ranks the effectiveness of different controls. This hierarchy consists of five levels, starting with elimination - the most effective control - which involves removing the hazard completely from the laboratory, such as replacing a hazardous substance with a less hazardous one. The second most effective control is substitution, where you replace the hazard with a less hazardous one, such as using different equipment or methods. The third is engineering, which involves isolating the hazard from staff by using ventilation, barriers, or guards. Administrative is fourth on the list, and involves changing the way staff work with the hazard through training and procedures. Last is personal protective equipment (PPE), which should be used as a last resort or in combination with other controls as it does not eliminate or reduce the hazard itself. You should choose the most effective and feasible control for each hazard and assign responsibilities, deadlines, and resources for implementing them. Additionally, you should monitor and evaluate the effectiveness of these actions and update your risk matrix accordingly.