Questions are an inevitable part of any presentation, and they can be a great opportunity to clarify your points, demonstrate your expertise, and build rapport with your audience. However, they can also be challenging, especially if they are off-topic, irrelevant, or hostile. To handle questions effectively, you need to have a strategy. Decide when and how you will take questions, whether during or after your presentation, and how much time you will allocate for them. Prepare some answers for the most likely or common questions, and anticipate some potential objections or criticisms. Be polite, respectful, and confident when answering questions, and avoid getting defensive or argumentative. If you don't know the answer, admit it and offer to follow up later. If the question is off-topic or irrelevant, acknowledge it and redirect it to the main focus of your presentation.