The best turbulence model for simulations is determined by many factors, such as the flow regime, geometry, Reynolds number, accuracy requirements, and computational budget. To make a good decision, start with a simple and robust model like RANS and check if it meets expectations. If not, try a more advanced model like LES or DES and compare the results. Additionally, use appropriate grid resolution and quality for the chosen model. RANS models need finer grids near the walls while LES and DES models require finer grids in high turbulence regions. DNS models need very fine grids throughout. Validate the model against experimental data or DNS results, if available, by assessing global and local quantities such as lift, drag, pressure, velocity, and turbulence intensity. Furthermore, analyze the sensitivity of your model to input parameters like boundary conditions, initial conditions, and model coefficients by trying different values to see how they affect the results. Finally, document your model selection and validation process while reporting any uncertainties or limitations of your simulations.