To efficiently utilize Chrome DevTools for JavaScript debugging, it's important to learn the keyboard shortcuts and commands that can save you time. You can also use debugger statements to pause the execution of your JavaScript code and inspect the values and state of your variables and expressions. Additionally, you can use the console.log(), console.warn(), console.error(), and console.assert() methods to print messages, warnings, errors, and assertions to the Console tab. The console.dir() method can be used to display the properties of an object in a tree structure, or you can use the $0, $1, $2, ... variables to access elements selected in the Elements tab. Furthermore, you can utilize the debugger protocol or Chrome DevTools Protocol to communicate with Chrome DevTools programmatically and automate tasks such as taking screenshots or profiling performance.