When attempting to synchronize data in a multi-region cloud-based relational database, there is no definitive answer. However, there are best practices to follow. First, identify the goals and requirements of your application such as availability, consistency, performance, scalability, security, and compliance. This will help you determine the most fitting type and method of synchronization. Additionally, select the right database service and configure it accordingly. For example, you may opt for a managed service with built-in replication or a self-hosted option with customizable settings. Furthermore, monitor and test your synchronization regularly to ensure it is working properly and detect any issues or errors. Lastly, address any conflicts or anomalies that may arise due to synchronization. This could include duplicate keys, missing values or inconsistent states. Conflict resolution strategies like last write wins or majority wins can be used to resolve conflicts while data validation and verification techniques like checksums or timestamps can be used to detect and correct data anomalies.