To use the matrix, you need to follow these steps: first, brainstorm the assumptions and hypotheses that underpin your product vision and strategy. You can use tools like the lean canvas, the value proposition canvas, or the business model canvas to help you structure your thinking. Then, rate each assumption and hypothesis on a scale of 1 to 5 for impact and uncertainty, with criteria such as customer value, revenue potential, competitive advantage, market size, customer feedback, industry trends, or data analysis to guide your ratings. After that, plot each assumption and hypothesis on the matrix according to their scores using sticky notes, spreadsheets, or online tools like Miro or Airtable. Finally, analyze the results and prioritize the assumptions and hypotheses in the high impact/high uncertainty quadrant. These are the ones that pose the greatest threat or opportunity for your product and require the most validation or invalidation. You can also consider those in the high impact/low uncertainty quadrant as they support your product's core value proposition and differentiation.