The fourth step is to develop and document your risk response strategies, which are the actions you will take to prevent, reduce, transfer, accept, or exploit the risks. You should also assign roles and responsibilities for each risk response, and define the triggers, indicators, and metrics that will alert you to the changes in the risk status. For instance, you can implement best practices and standards to avoid clinical risks, allocate contingency funds to mitigate financial and operational risks, outsource or insure to shift some or all of the risk to a third party, acknowledge and monitor the risk while preparing for any consequences if it occurs, or take advantage of positive risks such as opportunities for innovation.