The first step to prioritize Windows 10 patches is to assess the risk level of each patch. You can use the Microsoft Security Response Center (MSRC) portal to find out the severity rating, the impact, and the exploitability of each patch. The severity rating ranges from critical to low, and indicates how likely the patch is to prevent a serious vulnerability. The impact describes the type of damage that could result from exploiting the vulnerability, such as remote code execution, denial of service, or information disclosure. The exploitability indicates how easy or hard it is to exploit the vulnerability, and whether there are any known attacks or exploits in the wild. You should prioritize patches that have high severity, high impact, and high exploitability ratings, as they pose the most immediate threat to your system.